
Each Robot Master has his own unique weapons and vulnerabilities.

Throughout Mega Man's new adventure he'll take on the malfunctioning-infected robots and classic-style bosses with the unique gameplay only found in a Mega Man® game. Infected robots are on a rampage and out of control as they destroy the city and hold everyone hostage! Who's behind this mess? It's up to Mega Man to take on this sinister threat and get to the bottom of this viral mystery. It spreads through the world like wildfire bringing down robots everywhere.

Wily of all the instances where Mega Man had to save Wily from himself. Light alludes to Roboenza in Sonic the Hedgehog #250 when reminding Dr.

Roboenza was alluded to in Mega Man #20 when Mega Man and Bass were stuck in a time loop nearing the climax of the issue. In the end of the story it's said Bass was cured after defeating Wily. Later in the story, both Bass and Treble felt ill and Treble gave Bass a medicine, but when seeing Treble's state, Bass decided to shove the medicine down Treble's throat to cure him, and he faced Wily ill, causing Bass to go berserk (since all robots infected with Roboenza go berserk after one month of being ill). Mega Man and Proto Man go after the eight bosses to obtain chips with data for the medicine-making machine, and as Bass had defeated them before their arrival, they only had to take the chips. In the manga Rockman 10 -Extra F-, which is based on Bass' story from the game, Roll became ill with Roboenza.

Bass and Treble with Roboenza in Rockman 10 -Extra F.
